Role of Endocannabinoid System Modulation

THIS IS A SUBTITLE FOR YOUR NEW POSTNEUROPROTECTION IN OXIDATIVE STRESS-RELATED NEURODEGENERATIVE DISEASES: ROLE OF ENDOCANNABINOID SYSTEM MODULATION

Numerous studies also suggest an important interplay between the endocannabinoid lipid signaling system, plant-derived cannabinoids such as cannabidiol, and various redox-dependent processes (17, 138, 155, 227, 251, 336). Dysregulation of endocannabinoid production and/or receptor expression have been reported under different pathophysiological conditions, including nociception (2, 290), emotional disorders (80, 114), energy imbalance (59, 81, 305), neurodegenerative diseases (5, 85, 87), cancer (337), diabetes and metabolic disorders (81, 247, 322), and cardiovascular disease (226, 280, 314) among others.